MYRIP Antibody, HRP conjugated

1. The role of MyRIP in Ca(2+)-driven exocytosis requires both MyoVa- and actin-binding potential. PMID: 26675235
2. Myrip couples the retention of secretory granules in the cell cortex, their transport to the plasma membrane, and their attachment to the plasma membrane, thus promoting secretion. PMID: 22396429
3. A Rab27a/MyRIP/myosin Va complex is involved in linking von-Willebrand factor (Vwf) to the peripheral actin cytoskeleton of endothelial cells to allow full maturation and prevent premature secretion of vWF. PMID: 21740491
4. A new potentially protective effect was identified at rs2679798 in MYRIP. PMID: 20861866
5. a molecular complex composed of Rab27A, MyRIP and myosin VIIa bridges retinal melanosomes to the actin cytoskeleton and thereby mediates the local trafficking of these organelles PMID: 11964381
6. Slac2c/MyRIP is part of a complex mediating the interaction of secretory granules with cortical actin cytoskeleton PMID: 14517322
7. During primate spermiogenesis, dynein, myosin Va, MyRIP and Rab27b that compose microtubule-based and actin-based vesicle transport systems are actually present in the manchette and might possibly be involved in intramanchette transport. PMID: 18478159
8. Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. PMID: 19270261
9. Slac2-c/MyRIP contains an N-terminal Slp homology domain (SHD) and functions as a linker protein that interacts with myosin Rab27A/B, VIIa/Va, and actin. PMID: 12221080

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HGNC: 19156

OMIM: 611790

KEGG: hsa:25924

STRING: 9606.ENSP00000301972

UniGene: Hs.594535